November 4th, 2021

Posters

The 2021 BSOBC will include a virtual poster session for graduate students and postdocs, to provide presenters with an opportunity to share their research and to engage with other attendees from industry and academia.

 

10:35–11:20am – Virtual Poster Session 1

 

Singlet Oxygen-Degradable Nanomaterials for Enhanced Photodynamic Therapy
Valentina Brega, Samuel Thomas group, Tufts University

Hydrogen-atom transfer/radical-polar crossover platform for Csp3-H etherification
Nicholas Fitzpatrick, Patricia Musacchio group, Worcester Polytechnic Institute

Cyclophilin B secretion induced by sanglifehrin A reduces collagen secretion by myofibroblasts and organ fibrosis in experimental models
Hope Flaxman, Christina Woo group, Harvard University

Synthesis of trans-Vicinal Diols via A Stereochemical Editing Strategy
Xin Gu, Alison Wendlandt group, Massachusetts Institute of Technology

Engineering Novel Rocaglates through Efficient Chemical Synthesis and Flow Chemistry to Target DEAD-Box Helicases
Jeffrey Henry, John Porco group, Boston University

Utilization of mRNA display to comprehensively analyze sequence preferences for N-terminal processing of peptides initiated with an unnatural amino acid
Satoru Horiya, Isaac Krauss group, Brandeis University

Controlled Bioorthogonal Catalyst Self-Assembly and Activity Using Rationally Designed Polymer Scaffolds
Rui Huang, Vincent Rotello group, UMass Amherst

VADER: Virus-Assisted Directed Evolution of tRNAs in Mammalian Cells
Lily Jewel, Abhishek Chatterjee group, Boston College

Metalloradical Activation of In Situ-Generated α-Alkynyldiazomethanes for Asymmetric Radical Cyclopropanation of Alkenes
Jing (Nicca) Ke, X. Peter Zhang group, Boston College

E- and Z- Trisubstituted Alkenyl Bromides through Catalytic Cross-Metathesis for Complex Molecule Synthesis
Tobias Koengeter, Amir Hoveyda group, Boston College

Discovery of C13-aminobenzoyl cycloheximide derivatives as potent inhibitors of translation elongation
Yumi Koga, Brian Liau group, Harvard University

Mechanisms of resistance to the small-molecule antiviral Arbidol
Zhenyu Li, Tijana Ivanovic group, Brandeis University

Photochemical Dearomative Ring Expansion of Pyridines: Development and Application to Late-Stage Modification
Matthew Mailloux, Aaron Beeler group, Boston University

Synthesis of organofluorine hydrazones and their evaluation for potential mitochondrial antioxidant therapy for alleviating preeclampsia
Maxim Mastyugin, Béla Török group, UMass Boston

Convergent Total Synthesis of Streptothricin Analogs
Brandon Miller, Roman Manetsch group, Northeastern University

Site-selective, Mn(salen)-catalyzed, oxidative debenzylation of carbohydrates
Elisabetta Ronchi, Eric Jacobsen group, Harvard University

Synthesis of Polycyclic Fused-Ring Systems via One-Pot GBB and PS Annulation
Takeru Saito, Wei Zhang group, UMass Boston

Structure−Activity Relationship of Peptide-Conjugated Chloramphenicol for Inhibiting Escherichia coli
Adrianna Shy, Bing Xu group, Brandeis University

Multiparameter optimization: azaspirocycles for visceral leishmaniasis
Quillon Simpson, Michael Pollastri group, Northeastern University

A Chemoenzymatic Synthesis of the Mycobacterial Galactan
Katherine Taylor, Laura Kiessling group, Massachusetts Institute of Technology

Constitutive Activation of GLP-1R via Covalent Capture
Özge Ünsal, Krishna Kumar group, Tufts University

in vitro and in vivo anticoagulant activity of sulfated poly-amido-saccharides
Maria Varghese, Mark Grinstaff group, Boston University

Designing out off-targets of PROTACs
Sreekanth Vedagopuram, Amit Choudhary group, Broad Institute

C−Boron Enolates Enable Palladium Catalyzed Carboboration of Internal 1,3-Enynes
Ziyong Wang, Shih-Yuan Liu group, Boston College

In Vitro Selection of Base-Clickable Next-Generation Nucleic Acid Affinity Reagents
Kevin Wu, Jia Niu group, Boston College

Enantioselective Cycloaddition Reactions Enabled via the Design of a Novel Chiral Auxiliary on Boron
Peilin Xu, James Morken group, Boston College

 

 

3:00–3:45pm – Virtual Poster Session 2

 

Mapping the lenalidomide interactome by chemical proteomics
Yuka Amako, Christina Woo group, Harvard University

One-pot Sequential GBB and [4+2] Cycloaddition for Stereoselective Synthesis of Novel Polyheterocyclic Scaffolds
John Mark Awad, Wei Zhang group, UMass Boston

Synthesis of aryl-orthoesters: New building blocks for organic semiconductors
Nicole Berry, Malika Jeffries-EL group, Boston University

New Frontiers in Synthetic Biology: Leveraging BN/CC Isosterism to Develop Novel Biochemical Space
Kevin Byrne, Shih-Yuan Liu group, Boston College

Adapting Covalent Peptides for Activity-Based Protein Profiling
Sarah Canarelli, Eranthie Weerapana group, Boston College

Towards Non-Stick Silk: Controlling the Hydrophobicity of Silk Fibroin Protein via Fluorocarbon Functionalization
Julia Fountain, Krishna Kumar group, Tufts University

Medicinal chemistry optimization of CBL0137 as a lead for Human African Trypanosomiasis drug development
Pradip Gadekar, Michael Pollastri group, Northeastern University

A Heavy-Metal Trojan Horse: Enterobactin-Based Delivery of Platinum(IV) Prodrugs to Gram-Negative Bacterial Pathogens
Chuchu Guo, Elizabeth Nolan group, Massachusetts Institute of Technology

Total Synthesis of Sarcodictyin A & B
Weipeng Hu, James Morken group, Boston College

Semi-synthesis of ubiquitinated PTEN protein by expressed protein ligation
Reina Iwase, Philip Cole group, Harvard University Medical School

Bioorthogonal Hydroamination of Alkynes
Dahye Kang, Justin Kim group, Dana-Farber Cancer Institute

Scalable Synthesis of Piperarbornines C-E and β-Truxinates Enabled by a Diastereoselective [2+2] Photocycloaddition in Continuous Flow
Jason Lenihan, Aaron Beeler group, Boston University

Stereochemistry and total synthesis of neonorhalichondrin B
Rachelle Quach, Yoshito Kishi group, Harvard University

Harnessing Underexplored Diazo Reagents for the Modular Synthesis of Cyclopropane-Fused N-Heterocycles
Matthieu Richter, Stuart Schreiber group, Broad Institute

Umpolung Bioconjugation Reactions of Genetically Encoded 5-hydroxytryptophan
Soumya J. S. Roy, Abhishek Chatterjee group, Boston College

De novo asymmetric approach towards diverse array of aminosugars synthesis
Nishikant Satam, George O’Doherty group, Northeastern University

Self-Assembled Polysaccharide Mimetic Nanoparticles
Kaitlynn Sockett, Mark Grinstaff group, Boston University

Identification of in silico Plasmodium falciparum formate nitrite transporter (PfFNT) inhibitors via virtual screen
Alicia Wagner, Roman Manetsch group, Northeastern University

Synthesis of Oligomannose Azides for the Development of HIV Vaccines
Bokai Xu, Isaac Krauss group, Brandeis University

Catalytic Radical N-Heterobicyclization Involving α-Metalloaminyl Radicals via Co(II)-MRC: New Mode of Asymmetric Induction
Hao Xu, X. Peter Zhang group, Boston College

Synthesis and Unusual Reactivity of Compounds with Trifluoromethyl- and Fluoro-Substituted Carbon
Shibo Xu, Amir Hoveyda group, Boston College

Rational design of silicon-based zinc ionophores with antibacterial activity
Kei Yamada, Amit Choudhary group, Broad Institute

Total Synthesis of Spiromeroterpenoids: A Fragment Coupling approach
Feng Yang, John Porco group, Boston University

Localized bioorthogonal nanozymes for in vivo breast cancer imaging and therapy
Xianzhi Zhang, Vincent Rotello group, UMass Amherst

Hydrogen-atom transfer/radical-polar crossover platform for Csp3-H fluorination
Yufei Zhang, Patricia Musacchio group, Worcester Polytechnic Institute