Agenda
9:00 - Organizer's Welcome
Daniel Smaltz, Senior Principal Scientist, Pfizer
9:15 - 9:35 Synthesis and Study of Complex Molecule Antibiotics
Kyan D’Angelo, Mo Movassaghi group, Massachusetts Institute of Technology
9:35 - 9:55 Rational Design of Bifunctional Molecules That Alter the Specificity of Serine/Threonine and Tyrosine Kinases
Veronika Shoba, Amit Choudhary group, Broad Institute & Harvard Institutes of Medicine
9:55 - 10:15 Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small Molecule Inhibitors Against Pathogenic Amoeba Glucokinases
Mintesinot Kassu, Roman Manetsch group, Northeastern University
10:15 - 10:35 Unraveling Cysteine Oxidation in the Mitochondria
Eleni Kisty, Eranthie Weerapana group, Boston College
10:35 - Virtual Poster Session 1
11:20 Break
11:35 - Keynote Presentation: Target Identification With Photo-Affinity Labeling
Christina Woo, Associate Professor of Chemistry and Chemical Biology, Harvard University
12:35pm - Lunch break
1:35 - Afternoon Session Opening Remarks
Emma Edelstein, Senior Scientist, Merck
1:40 - 2:00 Deep Learning to Design Nuclear-Targeting Abiotic Miniproteins
Carly Schissel, Bradley Pentelute group, Massachusetts Institute of Technology
2:00 - 2:20 Novel Reaction Discovery with Rapid HTS via Infrared Spectroscopy and Electrochemical Enzyme Catalysis
Jessie Zhen, Scott Schaus group, Boston University
2:20 - 2:40 Molecular Design of Secretin Peptides to Modulate Receptor Function
Kathleen Sicinski, Krishna Kumar group, Tufts University
2:40 - 3:00 Identifying Scaffolding and Allosteric Functions of LSD1 in AML
Amanda Waterbury, Brian Liau group, Harvard University
3:00 - Virtual Poster Session 2
3:45 - Break
3:55 - Keynote Presentation: Oral Inhibitors of the SARS-CoV-2 Main Protease for the Treatment of COVID-19
Dafydd Owen, Senior Science Director, Medicine Design, Pfizer
4:50 - Closing Remarks
Lei Zhang, Senior Director, Medicine Design, Pfizer
5:00 - Symposium Closes