Boston Symposium on organic & bioorganic chemisty

9:00 - Organizer's Welcome

Daniel Smaltz, Senior Principal Scientist, Pfizer

9:15 - 9:35 Synthesis and Study of Complex Molecule Antibiotics

Kyan D’Angelo, Mo Movassaghi group, Massachusetts Institute of Technology

9:35 - 9:55 Rational Design of Bifunctional Molecules That Alter the Specificity of Serine/Threonine and Tyrosine Kinases

Veronika Shoba, Amit Choudhary group, Broad Institute & Harvard Institutes of Medicine

9:55 - 10:15 Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small Molecule Inhibitors Against Pathogenic Amoeba Glucokinases

Mintesinot Kassu, Roman Manetsch group, Northeastern University

10:15 - 10:35 Unraveling Cysteine Oxidation in the Mitochondria

Eleni Kisty, Eranthie Weerapana group, Boston College

10:35 - Virtual Poster Session 1

11:20 Break

11:35 - Keynote Presentation: Target Identification With Photo-Affinity Labeling

Christina Woo, Associate Professor of Chemistry and Chemical Biology, Harvard University

12:35pm - Lunch break

1:35 - Afternoon Session Opening Remarks

Emma Edelstein, Senior Scientist, Merck

1:40 - 2:00 Deep Learning to Design Nuclear-Targeting Abiotic Miniproteins

Carly Schissel, Bradley Pentelute group, Massachusetts Institute of Technology

2:00 - 2:20 Novel Reaction Discovery with Rapid HTS via Infrared Spectroscopy and Electrochemical Enzyme Catalysis

Jessie Zhen, Scott Schaus group, Boston University

2:20 - 2:40 Molecular Design of Secretin Peptides to Modulate Receptor Function

Kathleen Sicinski, Krishna Kumar group, Tufts University

2:40 - 3:00 Identifying Scaffolding and Allosteric Functions of LSD1 in AML

Amanda Waterbury, Brian Liau group, Harvard University

3:00 - Virtual Poster Session 2

3:45 - Break

3:55 - Keynote Presentation: Oral Inhibitors of the SARS-CoV-2 Main Protease for the Treatment of COVID-19

Dafydd Owen, Senior Science Director, Medicine Design, Pfizer

4:50 - Closing Remarks

Lei Zhang, Senior Director, Medicine Design, Pfizer

5:00 - Symposium Closes